Then, we propose a PSSP method based on the proposed multiscale convolution module and ICA module.
We introduce a new multiscale convolution module and an improved channel attention (ICA) module into the generator to generate the secondary structure, and then a discriminator is designed to conflict with the generator to learn the complicated features of proteins. To explore a new technique of PSSP, this study introduces the concept of an adversarial game into the prediction of the secondary structure, and a conditional generative adversarial network (GAN)-based prediction model is proposed. Driven by deep learning, the prediction accuracy of the protein secondary structure has been greatly improved in recent years. Protein secondary structure prediction (PSSP) aims to construct a function that can map the amino acid sequence into the secondary structure so that the protein secondary structure can be obtained according to the amino acid sequence. Prediction of the protein secondary structure is a key issue in protein science. 2School of Software, Yunnan University, Kunming, Yunnan, China.1Engineering Research Center of Cyberspace, Yunnan University, Kunming, Yunnan, China.Only some proteins have a quaternary structure as well.Ĭopyright © 2023, StatPearls Publishing LLC.Xin Jin 1,2 †, Lin Guo 1,2 †, Qian Jiang 1,2, Nan Wu 1,2 and Shaowen Yao 1,2* Each protein at least contains a primary, secondary, and tertiary structure.
The quaternary structure also influences the three-dimensional shape of the protein and is formed through the side-chain interactions between two or more polypeptides. The three-dimensional shape of a protein, its tertiary structure, is determined by the interactions of side chains from the polypeptide backbone. These hydrogen bonds create alpha-helix and beta-pleated sheets of the secondary structure. The secondary structure contains regions of amino acid chains that are stabilized by hydrogen bonds from the polypeptide backbone. The primary structure is comprised of a linear chain of amino acids. Only some proteins have a quaternary structure as well. Every protein at least contains a primary, secondary, and tertiary structure. A protein can be identified based on each level of its structure. They carry out a wide variety of organism functions, including DNA replication, transporting molecules, catalyzing metabolic reactions, and providing structural support to cells. Proteins are polypeptide structures consisting of one or more long chains of amino acid residues.
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